The Dialogue is led by cities, for cities. By being accountable to their citizens, mayors serve to amplify the voice of urban communities in having a say on what matters to them. Two overarching priorities unite cities in Africa and Europe: inclusive and sustainable growth that creates jobs, and social inclusion that leaves no one behind by extending access to services and participation in local decision-making. Within an evidence-based dialogue process, participating cities explore potentials for collaboration in several sectors and industries, involving immigrants and diaspora entrepreneurs. In 2022, the Mayors of Milan and Freetown, Giuseppe Sala and Yvonne Aki-Sawyerr, will co-host a Dialogue, including mayors from cities across both continents. The process aims to develop partnerships for sustainable initiatives on the ground and methods for city-led participatory and collaborative frameworks to be adapted in other contexts or existing intercontinental relations.